反应详情

A mixture of styrene (37.0 g, 356 mmol) and the N-methylnitrone solution from Example 5 is heated at 85° C. for 4 hours. After cooling, the phases were separated and the aqueous phase is extracted with chloroform (2×50 g). The combined chloroform extracts were combined with the initial organic phase, and the resultant mixture is washed with water (50 g). The organic phase is dried (K2CO3) and stripped of chloroform and excess styrene to give 2-methyl-5-phenylisoxazolidine (ca. 16 g).

1. temperatureAfter cooling
2. customthe phases were separated
3. extractionthe aqueous phase is extracted with chloroform (2×50 g)
4. washthe resultant mixture is washed with water (50 g)
5. dry with materialThe organic phase is dried (K2CO3)