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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 61075Generated: October 26, 2026

5-methyl-2-(1H-pyrazol-1-yl)benzoic acid → ((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1H-pyrazol-1-yl)phenyl)methanone

https://huagongshe.com/reaction/61075

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-methyl-2-(1H-pyrazol-1-yl)benzoic acidHCID 62514431—
Reactant((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanoneHCID 117728145—
Product((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1H-pyrazol-1-yl)phenyl)methanoneHCID 117727705—

Reaction Steps

The title compound was prepared following the same general protocol as described for ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone in Example A11 using 5-methyl-2-(1H-pyrazol-1-yl)benzoic acid. MS (ESI) 313 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09440982B2
Source datasetuspto-grants-2016_09
ORD IDord-bbb80748bcaa4c05af764503020ab09b
Source noteuspto-grants-2016_09