反应详情

2.88 g (0.0075 mol) of N-[4-(6-chloro-2-ethylamino-pyrimidin-4-ylsulfamoyl)-phenyl]-acetamide were dissolved in 76 ml of 1N NaOH and boiled at reflux for 3 hours. The mixture was extracted with ethyl acetate, the aqueous phase was saturated with sodium chloride and the residual ethyl acetate was distilled on a rotary evaporator. Then, the aqueous phase was made acid with 3N HCl and the precipitate which separated was filtered off under suction. After drying there were obtained 2.2 g (90%) of 4-amino-N-(6-chloro-2-ethylamino-pyrimidin-4-yl)-benzenesulfonamide as white crystals; m.p.: 172-173° C.

1. temperatureat reflux for 3 hours
2. extractionThe mixture was extracted with ethyl acetate
3. distillationthe residual ethyl acetate was distilled on a rotary evaporator
4. customthe precipitate which separated
5. filtrationwas filtered off under suction
6. customAfter drying there