2-(5-Fluoro-2-pyridinyl)-5-methylbenzoic acid → ((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(2-(5-fluoropyridin-2-yl)-5-methylphenyl)methanone

HRID 61081Notes

Reaction equation

HRID 61081 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1C1C=NN(C)C=1)=[O:11].[F:25][C:26]1[CH:27]=[CH:28][C:29](C2C=CC(C)=CC=2C(O)=O)=[N:30][CH:31]=1>>[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[C:29]1[CH:28]=[CH:27][C:26]([F:25])=[CH:31][N:30]=1)=[O:11]

Participants

3

Reactant 2

HCID 1177277412-(5-Fluoro-2-pyridinyl)-5-methylbenzoic acidHCID 117728145((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

Product 1

HCID 117727820((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(2-(5-fluoropyridin-2-yl)-5-methylphenyl)methanone

Procedure

The title compound was prepared following the same general protocol as described for ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone in Example A1 using 2-(5-fluoropyridin-2-yl)-5-methylbenzoic acid. MS (ESI) 342 (M+H).

Sources & evidence

ORD record
ord-ba27b70893a34c37ac2cb67a3e0d056b
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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