3-Fluorobenzoyl chloride → HCID 892213, compound

HRID 610866Notes

Reaction equation

HRID 610866 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[CH3:11][NH:12][C:13]([CH3:16])([CH3:15])[CH3:14]>>[CH3:11][N:12]([C:13]([CH3:16])([CH3:15])[CH3:14])[C:5](=[O:6])[C:4]1[CH:8]=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=1

Participants

3

Reactant 2

HCID 743763-Fluorobenzoyl chlorideHCID 84552N-Methyl-tert-butylamine

Product 1

HCID 892213HCID 892213, compound

Procedure

3-Fluorobenzoyl chloride was reacted with N-methyl-N-tert-butylamine using General Method E1 or E2 to produce N-methyl-N-(tert-butyl)-3-fluorobenzamide. This compound was used in General Method A to prepare the title compound. Kugelrohr distillation afforded 12.07 g of analytically pure desired material. m.p. 32-35° C.

Sources & evidence

ORD record
ord-8bc30d7355e646c8abea3f595e15353e
Source dataset
uspto-grants-1999_12
Patent number
US05998466

Reaction notes

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