Ethanol → HCID 86164042, compound

Participants

Reaction Steps

A mixture of the compound of Example h (10 mmol) and ethanol (75 mL) was ref luxed for 1 h. The mixture was concentrated and the residue dissolved in ethyl acetate. The solution was washed twice with water and the solvent removed to yield the crude product, which was recrystallized from hexane. GC/MS showed some remaining isocyanate so the solid was dissolved in ethanol and refluxed again with approx. 0.1 g diazobisbicyclooctane. FID/GC indicated a complete reaction and the ethanol was removed and the title compound recovered. m.p. 109-110° C.

Provenance & Evidence