6'-Methyl-2,3'-bipyridine-2'-carboxylic acid → ((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(6'-methyl-[2,3'-bipyridin]-2'-yl)methanone

HRID 61094Notes

Reaction equation

HRID 61094 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1C(C1C=C(C)C=CC=1C1C=NN(C)C=1)=O.[CH3:25][C:26]1[N:31]=[C:30]([C:32]([OH:34])=O)[C:29]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=2)=[CH:28][CH:27]=1>>[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:32]([C:30]1[C:29]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=2)=[CH:28][CH:27]=[C:26]([CH3:25])[N:31]=1)=[O:34]

Participants

3

Reactant 2

HCID 593637356'-Methyl-2,3'-bipyridine-2'-carboxylic acidHCID 117728145((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

Product 1

HCID 117727829((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(6'-methyl-[2,3'-bipyridin]-2'-yl)methanone

Procedure

The title compound was prepared following the same general protocol as described for ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone in Example A1 using 6′-methyl-[2,3′-bipyridine]-2′-carboxylic acid. MS (ESI) 325 (M+H).

Sources & evidence

ORD record
ord-6255426375404b7eb6d8cad68c7ef743
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

Loading…