2-Bromo-5-chloropyridine → HCID 117727789, compound

HRID 61098Notes

Reaction equation

HRID 61098 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[C:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)=[CH:16][CH:15]=[C:14]([CH3:24])[N:13]=1)=[O:11].Br[C:26]1[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][N:27]=1>>[Cl:32][C:29]1[CH:30]=[CH:31][C:26]([NH:1][CH2:2][C@@H:3]2[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]2[C:10]([C:12]2[C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[CH:16][CH:15]=[C:14]([CH3:24])[N:13]=2)=[O:11])=[N:27][CH:28]=1

Participants

3

Reactant 2

HCID 8170982-Bromo-5-chloropyridineHCID 117727829((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(6'-methyl-[2,3'-bipyridin]-2'-yl)methanone

Product 1

HCID 117727789HCID 117727789, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A44 using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(6′-methyl-[2,3′-bipyridin]-2′-yl)methanone and 2-bromo-5-chloropyridine. MS (ESI) 436 (M+H).

Sources & evidence

ORD record
ord-d1dbb810b6a244e89556e1037134e4ce
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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