Water → HCID 19599884, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6.597 g (48.09 mmol) of N-allyl-3-furylmethylamine and 18.0 g (144 mmol) of 2-bromoethanol in 100 ml of N,N-dimethylformamide, 33.2 g of potassium carbonate was added, followed by overnight stirring at 90° C. The reaction mixture was poured into water and extracted with dichloromethane 3 times. The combined organic layer was dried over anhydrous magnesium sulfate; the solvent was distilled off under reduced pressure. The resulting crude product was purified by silica gel column chromatography (hexane/ethyl acetate=3/1 to 1/1) to yield 2-[allyl-(3-furylmethyl)amino]ethanol.

Provenance & Evidence