反应详情

A solution of 3.347 g (17.69 mmol) of 1-benzyl-4-piperidinone and 1.75 g (17.7 mmol) of cyclohexylamine in 150 ml of toluene was refluxed under dehydrating conditions for 2.5 hours in a Dean-Stark trap. After the reaction mixture was cooled to room temperature, the solvent was distilled off under reduced pressure to yield N-(1-benzyl-4-piperidylidene)cyclohexylamine. This product was used for the next reaction without purification.

1. distillationthe solvent was distilled off under reduced pressure