Dimethylamine → HCID 67698165, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.190 g (0.483 mmol) of 5-(9,10,10-trioxo-9,10-dihydro-10λ6 -thioxanthene-3-carbonyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridine in 20 ml of acetic acid, 0.065 ml (0.72 mmol) of 50% aqueous dimethylamine and 0.059 ml (0.72 mmol) of 37% aqueous formaldehyde were added, followed by stirring at 100° C. for 60 minutes. After the solvent was distilled off under reduced pressure, the residual solution was alkalified with 5% aqueous sodium hydrogen carbonate, and extracted with dichloromethane 2 times. The combined organic layer was washed with water and dried over anhydrous sodium sulfate; the solvent was distilled off under reduced pressure. The resulting crude product was purified by silica gel column chromatography (chloroform/methanol=50/1 to 25/1) to yield the desired product.

Provenance & Evidence