Dimethylamine → HCID 19599959, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.945 g (3.18 mmol) of 7-(6-phenylhexyl)-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine in 20 ml of acetic acid, 0.34 g (3.8 mmol) of 50% aqueous dimethylamine and 0.31 g (3.8 mmol) of 37% aqueous formaldehyde were added, followed by stirring at 100° C. for 30 minutes. After the solvent was distilled off under reduced pressure, the residual solution was alkalified with aqueous sodium hydroxide and extracted with dichloromethane 3 times. The combined organic layer was dried over anhydrous magnesium sulfate; the solvent was distilled off under reduced pressure. The resulting crude product was purified by silica gel column chromatography (ethyl acetate to ethyl acetate/methanol=4/1) to yield the desired product.

Provenance & Evidence