Triethylamine → HCID 19599881, compound

Participants

Reaction Steps

To a solution of 0.128 g of the above crude 5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride, 0.21 g (0.94 mmol) of 4-benzoylbenzoic acid and 0.43 ml (3.1 mmol) of triethylamine in 30 ml of dichloromethane, 0.14 ml (0.94 mmol) of diethyl cyanophosphonate was added dropwise under ice-cooling, followed by overnight stirring at room temperature. The reaction mixture was poured into aqueous sodium hydroxide and extracted with dichloromethane 3 times. The combined organic layer was dried over anhydrous magnesium sulfate; the solvent was distilled off under reduced pressure. The resulting crude product was purified by silica gel column chromatography (hexane/ethyl acetate=3/1 to 1/1) to yield the desired product.

Provenance & Evidence