Water → 2-[2-(3-Thienyl)ethyl]-1H-isoindole-1,3(2H)-dione

Participants

Reaction Conditions

Reaction Steps

To a solution of the above crude 2-(3-thienyl)ethyl methanesulfonate in 400 ml of N,N-dimethylformamide, 12.8 g (69.0 mmol) of potassium phthalimide was added, followed by overnight stirring at 100° C. After cooling to room temperature, the reaction mixture was added to water with vigorous stirring. The resulting precipitate was filtered, washed with water and dried to yield the desired product.

Provenance & Evidence