((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone → HCID 117728033, compound

HRID 61124Notes

Reaction equation

HRID 61124 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([NH:10][CH2:11][C@@H:12]3[C@H:17]([CH3:18])[CH2:16][CH2:15][CH2:14][N:13]3[C:19]([O:21]CC=C)=O)=[N:7][C:6]=2[CH:25]=1.NC[C@@H]1[C@H](C)CCCN1C([C:37]1[C:42]([N:43]2[N:47]=[CH:46][CH:45]=[N:44]2)=[CH:41][CH:40]=[C:39]([CH3:48])[N:38]=1)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([NH:10][CH2:11][C@@H:12]3[C@H:17]([CH3:18])[CH2:16][CH2:15][CH2:14][N:13]3[C:19]([C:37]3[C:42]([N:43]4[N:44]=[CH:45][CH:46]=[N:47]4)=[CH:41][CH:40]=[C:39]([CH3:48])[N:38]=3)=[O:21])=[N:7][C:6]=2[CH:25]=1

Participants

3

Reactant 2

HCID 117727634((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanoneHCID 117732742(2S,3R)-Allyl 2-(((5-chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidine-1-carboxylate

Product 1

HCID 117728033HCID 117728033, compound

Procedure

The title compound was synthesized following the same general protocol as described for (2S,3R)-allyl 2-(((5-chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidine-1-carboxylate in Example A27, using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone. ESI-MS (m/z): 466 [M+1]+.

Sources & evidence

ORD record
ord-fafadf7306544ff8ad3f33197ceb47c0
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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