Formaldehyde → HCID 19599931, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.647 g (4.502 mmol) of 6-[4-(4-chlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridine in 30 ml of acetic acid, 0.56 ml (5.40 mmol) of diethylamine and 0.44 g (5.40 mmol) of 37% aqueous formaldehyde were added, followed by stirring at 100° C. for 2 hours. After the solvent was distilled off under reduced pressure, the residual solution was alkalified with aqueous sodium hydroxide and extracted with dichloromethane 3 times. The combined organic layer was dried over anhydrous magnesium sulfate; the solvent was distilled off under reduced pressure. The resulting crude product was purified by silica gel column chromatography (ethyl acetate to ethyl acetate/methanol=9/1) to yield the desired product.

Provenance & Evidence