Dimethylamine → HCID 19600125, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.190 g (0.519 mmol) of 5-[4-(3-chlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridine in 10 ml of acetic acid, 0.070 ml (0.78 mmol) of 50% aqueous dimethylamine and 0.063 ml (0.78 mmol) of 37% aqueous formaldehyde were added, followed by stirring at 100° C. for 60 minutes. After the solvent was distilled off under reduced pressure, the residual solution was alkalified with 5% aqueous sodium hydrogen carbonate and extracted with dichloromethane 2 times. The combined organic layer was washed with water and dried over anhydrous sodium sulfate; the solvent was distilled off under reduced pressure. The resulting crude product was purified by silica gel column chromatography (chloroform/methanol=50/1) to yield the desired product.

Provenance & Evidence