Dimethylamine → HCID 19599879, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.210 g (0.572 mmol) of 5-(4-benzoylphenylsulfonyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridine in 10 ml of acetic acid, 77 mg (0.86 mmol) of 50% aqueous dimethylamine and 70 mg (0.86 mmol) of 37% aqueous formaldehyde were added, followed by stirring at 100° C. for 0.5 hours. After the solvent was distilled off under reduced pressure, the residual solution was alkalified with aqueous sodium hydroxide and extracted with ethyl acetate 3 times. The combined organic layer was dried over anhydrous magnesium sulfate; the solvent was distilled off under reduced pressure. The resulting crude product was crystallized from diethyl ether-hexane to yield the desired product.

Provenance & Evidence