HCID 53890816, compound → HCID 19600230, compound

Participants

Reaction Steps

A solution of the above 5-(stilbene-4-sulfonyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridine in 20 ml of toluene-ethanol (5:1) was hydrogenated at room temperature at atmospheric pressure over 49 mg (0.053 mmol) of chlorotris(triphenylphosphine)rhodium (I) until the starting material disappeared on TLC. After the reaction mixture was concentrated under reduced pressure, the resulting crude product was purified by silica gel column chromatography (hexane/ethyl acetate=6/1) and crystallized from diethyl ether-hexane to yield the desired product.

Provenance & Evidence