HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4,4-difluoro-1-((S)-1-phenylethyl)piperidin-2-yl)methanol → 2-((4,4-Difluoro-1-((S)-1-phenylethyl)piperidin-2-yl)methyl)isoindoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4,4-difluoro-1-((S)-1-phenylethyl)piperidin-2-yl)methanol | HCID 117727807 | — |
| Reactant | (2S,3R)-Benzyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-3-methylpiperidine-1-carboxylate | HCID 117731460 | — |
| Product | 2-((4,4-Difluoro-1-((S)-1-phenylethyl)piperidin-2-yl)methyl)isoindoline-1,3-dione | HCID 117728194 | — |
Reaction Steps
The title compound was prepared following the same general protocol as described for (2S,3R)-benzyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-3-methylpiperidine-1-carboxylate in Example A1 using (4,4-difluoro-1-((S)-1-phenylethyl)piperidin-2-yl)methanol (1.1 g, 97%). MS (ESI) 285 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440982B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-40832b6f8558467d8f7b7fba844a124f |
| Source note | uspto-grants-2016_09 |