HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-Ethylquinazoline-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Benzoic acid, 2-(ethylamino)- | HCID 66642 | — |
| Reactant | Sodium Cyanate | HCID 517096 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-Ethylquinazoline-2,4(1H,3H)-dione | HCID 825310 | — |
Reaction Steps
Am. Chem. Soc. (1933), pages 2113-2116 describes the reaction of N-ethylanthranilic acid with sodium cyanate and acetic acid and subsequent addition of sodium hydroxide to give 1,2,3,4-tetrahydro-1-ethyl-2,4-dioxoquinazoline. However, disadvantages of this process are the low space yield, because of the dilute reaction solution, and the very high excess of sodium hydroxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06001831 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-b8d99ac57f3c45f2a2fa37b559ad9fca |
| Source note | uspto-grants-1999_12 |