HCID 19597257, compound → HCID 19597260, compound

Participants

Reaction Steps

A suspension of 1-benzyloxy-3-[2-[(diethoxyphosphoryl)acetyl]hydrazino]-6-(4-methyl-2-phenyl-1H-imidazol-1-yl)-7-trifluoromethylquinoxalin-2(1H)-one (1.8 g, 2.6 mmol) and 50 mg of 5% palladium on carbon in 50 ml of ethanol was hydrogenated at room temperature and atmospheric pressure for 9 h. The catalyst was removed by filtration, the filtrate evaporated to dryness in vacuo and the residue finally triturated with ether to give 1.51 g (97%) of the title compound. M.p.>177° C. decomp. 1H-NMR (DMSO-d6): δ 1.10-1.22 (m, 6H), 2.23 (s, 3H), 2.98 (d, 2H), 4.00 (quint., 4H), 7.12 (s, 1H), 7.18-7.30 (m, 5H), 7.31 (s, 1H), 7.92 (s, 1H), 10.24 (s, 2H), 12.52 (br. s, 1H).

Provenance & Evidence