2-Bromo-5-chloropyridine → HCID 117727689, compound

HRID 61150Notes

Reaction equation

HRID 61150 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][C:7]([F:10])([F:9])[CH2:6][CH2:5][N:4]1[C:11]([C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[N:24]=[CH:23][CH:22]=[N:21]1)=[O:12].Br[C:26]1[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][N:27]=1>>[Cl:32][C:29]1[CH:30]=[CH:31][C:26]([NH:1][CH2:2][C@@H:3]2[CH2:8][C:7]([F:10])([F:9])[CH2:6][CH2:5][N:4]2[C:11]([C:13]2[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=2[N:20]2[N:24]=[CH:23][CH:22]=[N:21]2)=[O:12])=[N:27][CH:28]=1

Participants

3

Reactant 2

HCID 8170982-Bromo-5-chloropyridineHCID 117727855HCID 117727855, compound

Product 1

HCID 117727689HCID 117727689, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A44 using (2-(aminomethyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone and 2-bromo-5-chloropyridine. MS (ESI) 447 (M+H).

Sources & evidence

ORD record
ord-fe062d7c8c884127be01b7455a3ffce8
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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