Water → HCID 178517755, compound

HRID 611504Notes

Reaction equation

HRID 611504 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:8])=[N:6][CH:7]=1.[Br:9]Br.O>C(O)(=O)C>[Br:9][C:4]1[C:5]([OH:8])=[N:6][CH:7]=[C:2]([Cl:1])[CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 1785160645-chloropyridin-2-ol

Product 1

HCID 178517755HCID 178517755, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 5-chloro-2-hydroxypyridine (100 g) and bromine (40.1 mL) in acetic acid (400 mL) was stirred at r.t. for 1 h. The mixture was poured into 3 L of water and stirred for 30 min then filtered. The residual solid was washed with 2 L of cold water, air dried and then coevaporated with toluene three times and with benzene two times. The white solid (81 g) so obtained was used in the subsequent reaction.

Workup

  1. stirringstirred for 30 min
  2. filtrationthen filtered
  3. washThe residual solid was washed with 2 L of cold water, air
  4. customdried

Sources & evidence

ORD record
ord-90de5f25e1474c908833851325b69b93
Source dataset
uspto-grants-1999_12
Patent number
US06001843

Reaction notes

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