3-Chlorobenzaldehyde → HCID 4019451, compound

HRID 611508Notes

Reaction equation

HRID 611508 reaction equation
[CH3:1][O:2][C:3](=[O:16])[C@H:4]([CH2:6][C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9][CH:8]=1)[NH2:5].[Cl:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=1)[CH:21]=O>>[Cl:17][C:18]1[CH:19]=[C:20]([CH:21]2[C:8]3[NH:9][C:10]4[C:15]([C:7]=3[CH2:6][CH:4]([C:3]([O:2][CH3:1])=[O:16])[NH:5]2)=[CH:14][CH:13]=[CH:12][CH:11]=4)[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 114773-ChlorobenzaldehydeHCID 77980L-Tryptophan, methyl ester

Product 1

HCID 4019451HCID 4019451, compound

Procedure

The same method as employed in the preparation of intermediate 1 and 2 but starting from racemic tryptophan methyl ester and 3-chlorobenzaldehyde gave the title compound as white solid m.p.:150-160° C.

Sources & evidence

ORD record
ord-c17c3451f7324a6ba31c60fb75f4b68d
Source dataset
uspto-grants-1999_12
Patent number
US06001847

Reaction notes

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