HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzaldehyde → methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzaldehyde | HCID 68023 | — |
| Reactant | L-Tryptophan, methyl ester | HCID 77980 | — |
| Product | methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylate | HCID 4691803 | — |
Reaction Steps
The same method as employed in the preparation of intermediate 1 and 2 but starting from racemic tryptophan methyl ester and 4-fluorobenzaldehyde gave the cis isomer as white crystals m.p.:92° C. and the trans isomer as pale yellow crystals m.p.:183° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06001847 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-96ebd100352040148b815e97d182751d |
| Source note | uspto-grants-1999_12 |