2-Chloro-5-(trifluoromethyl)pyrimidine → HCID 117727642, compound

HRID 61151Notes

Reaction equation

HRID 61151 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][C:7]([F:10])([F:9])[CH2:6][CH2:5][N:4]1[C:11]([C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[N:24]=[CH:23][CH:22]=[N:21]1)=[O:12].Cl[C:26]1[N:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][N:27]=1>>[F:9][C:7]1([F:10])[CH2:6][CH2:5][N:4]([C:11]([C:13]2[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=2[N:20]2[N:24]=[CH:23][CH:22]=[N:21]2)=[O:12])[C@H:3]([CH2:2][NH:1][C:26]2[N:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][N:27]=2)[CH2:8]1

Participants

3

Reactant 2

HCID 133170192-Chloro-5-(trifluoromethyl)pyrimidineHCID 117727855HCID 117727855, compound

Product 1

HCID 117727642HCID 117727642, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A45 using (2-(aminomethyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone and 2-chloro-5-(trifluoromethyl)pyrimidine. MS (ESI) 482 (M+H).

Sources & evidence

ORD record
ord-d27c14a6bbaa4953953359e47ccfc811
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

Loading…