HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Hydroxyquinoline → HCID 19597399, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Hydroxyquinoline | HCID 1923 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-METHYL P-HYDROXYACETANILIDE | HCID 221111 | — |
| Reactant | HCID 19597408 | HCID 19597408 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 19597399 | HCID 19597399 | — |
Reaction Steps
In a similar manner to Example 9, a mixture of 4-amino-5-(4-iodophenyl)-7-(tert-butyl)pyrrolo[2,3-d]pyrimidine (100 mg), potassium carbonate (104 mg), N-methyl-(4-acetamido)phenol (120 mg), 8-hydroxyquinoline (8 mg), copper (I) chloride (5 mg) and dimethylacetamide (8 ml) gave N-{4-[4-(4-amino-7-tert-butylpyrrolo[2,3-d]-pyrimidin-5-yl)phenoxy]phenyl}-N-methylacetamide. This structure was confirmed by 1H nmr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06001839 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-3dc0139738654c8fae8e5ee59ef87680 |
| Source note | uspto-grants-1999_12 |