80812-36-8 → ((2S,3R)-2-(((2,5-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

HRID 61153Notes

Reaction equation

HRID 61153 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[N:19]1[N:23]=[CH:22][CH:21]=[N:20]1)=[O:11].Cl[C:25]1[N:30]2[N:31]=[C:32]([CH3:34])[N:33]=[C:29]2[N:28]=[C:27]([CH3:35])[CH:26]=1>>[CH3:34][C:32]1[N:33]=[C:29]2[N:28]=[C:27]([CH3:35])[CH:26]=[C:25]([NH:1][CH2:2][C@@H:3]3[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]3[C:10]([C:12]3[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=3[N:19]3[N:23]=[CH:22][CH:21]=[N:20]3)=[O:11])[N:30]2[N:31]=1

Participants

3

Reactant 2

HCID 1557574480812-36-8HCID 89740674((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Product 1

HCID 117728072((2S,3R)-2-(((2,5-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Procedure

The title compound was prepared following the same general protocol as described for Example A1 using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone and 7-chloro-2,5-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine. ESI-MS (m/z): 460 [M+1]+.

Sources & evidence

ORD record
ord-8c4a67caeb854d698af8c46c66e84a6f
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

Loading…