HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-hydroxyphenyl]benzenesulphonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxyphenyl]benzenesulphonamide | HCID 9956039 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-hydroxyphenyl]benzenesulphonamide | HCID 15429252 | — |
Reaction Steps
In a similar manner to Example 33, N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxyphenyl]benzenesulphonamide was reacted with boron tribromide in dichloromethane at -10° C. to give N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-hydroxyphenyl]benzenesulphonamide, m.p. 265-267° C. The structure was confirmed by 1H nmr and mass spectra.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06001839 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-ddbd2ed88a9c4c8cb8c0f028b6f37268 |
| Source note | uspto-grants-1999_12 |