7-Bromo-2-chloroquinazoline → HCID 117727843, compound

HRID 61156Notes

Reaction equation

HRID 61156 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[N:19]1[N:23]=[CH:22][CH:21]=[N:20]1)=[O:11].[Br:24][C:25]1[CH:34]=[C:33]2[C:28]([CH:29]=[N:30][C:31](Cl)=[N:32]2)=[CH:27][CH:26]=1>>[Br:24][C:25]1[CH:34]=[C:33]2[C:28]([CH:29]=[N:30][C:31]([NH:1][CH2:2][C@@H:3]3[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]3[C:10]([C:12]3[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=3[N:19]3[N:23]=[CH:22][CH:21]=[N:20]3)=[O:11])=[N:32]2)=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 457900527-Bromo-2-chloroquinazolineHCID 89740674((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Product 1

HCID 117727843HCID 117727843, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A1 using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone and 7-bromo-2-chloroquinazoline. ESI-MS (m/z): 520, 522 [M]+, [M+2]+.

Sources & evidence

ORD record
ord-eff0de56672d414da3275a5e08cc1627
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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