2-(2H-1,2,3-Triazol-2-yl)benzoic acid → (2-(2H-1,2,3-Triazol-2-yl)phenyl)((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)methanone

HRID 61160Notes

Reaction equation

HRID 61160 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[CH:17]=[C:16](C)[CH:15]=[CH:14][C:13]=1C1C=NN(C)C=1)=[O:11].[N:25]1[N:26](C2C=CC=CC=2C(O)=O)[N:27]=[CH:28][CH:29]=1>>[N:25]1[N:26]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:10]([N:4]2[CH2:5][CH2:6][CH2:7][C@@H:8]([CH3:9])[C@H:3]2[CH2:2][NH2:1])=[O:11])[N:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 213135922-(2H-1,2,3-Triazol-2-yl)benzoic acidHCID 117728145((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

Product 1

HCID 117728162(2-(2H-1,2,3-Triazol-2-yl)phenyl)((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)methanone

Procedure

The title compound was prepared following the same general protocol as described for ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone in Example A1 using 2-(2H-1,2,3-triazol-2-yl)benzoic acid. MS (ESI) 300 (M+H).

Sources & evidence

ORD record
ord-f90042a3a30e472cadf05b8b7bc52a91
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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