ethyl (RS)-3-[(piperidine-3-carbonyl)-amino]-propionate hydrochloride → HCID 178472072, compound

HRID 611602Notes

Reaction equation

HRID 611602 reaction equation
[Na+].[NH:2]([C:6]1[S:7][CH:8]=[C:9]([C:11]([O-:13])=O)[N:10]=1)[C:3]([NH2:5])=[NH:4].Cl.[NH:15]1[CH2:20][CH2:19][CH2:18][CH:17]([C:21]([NH:23][CH2:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])=[O:22])[CH2:16]1>>[NH:2]([C:6]1[S:7][CH:8]=[C:9]([C:11]([N:15]2[CH2:20][CH2:19][CH2:18][CH:17]([C:21]([NH:23][CH2:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])=[O:22])[CH2:16]2)=[O:13])[N:10]=1)[C:3]([NH2:5])=[NH:4]

Participants

3

Reactant 2

HCID 86754938ethyl (RS)-3-[(piperidine-3-carbonyl)-amino]-propionate hydrochlorideHCID 178512694HCID 178512694, compound

Product 1

HCID 178472072HCID 178472072, compound

Procedure

In analogy to Example 4, by coupling 2-guanidino-thiazole-4-carboxylic acid sodium salt with ethyl (RS)-3-[(piperidine-3-carbonyl)-amino]-propionate hydrochloride there is obtained ethyl (RS)-3-[[1-(2-guanidino-thiazole-4-carbonyl)-piperidine-3-carbonyl]-amino]-propionate as a white foam. MS: 397 (M+H)+.

Sources & evidence

ORD record
ord-4517aaab8e0b4be39e201d282f7a6b21
Source dataset
uspto-grants-1999_12
Patent number
US06001855

Reaction notes

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