4-Chloro-2-dimethylamino-pyrimidine-5-carboxylic acid benzylamide → HCID 178418259, compound

HRID 611642Notes

Reaction equation

HRID 611642 reaction equation
[CH2:1]([NH:8][C:9]([C:11]1[C:12](Cl)=[N:13][C:14]([N:17]([CH3:19])[CH3:18])=[N:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[SH2:21].[Na]>>[CH2:1]([NH:8][C:9]([C:11]1[C:12]([SH:21])=[N:13][C:14]([N:17]([CH3:19])[CH3:18])=[N:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 537230424-Chloro-2-dimethylamino-pyrimidine-5-carboxylic acid benzylamideHCID 86586439Sodium hydrogen sulphide

Product 1

HCID 178418259HCID 178418259, compoundYield 43.9%

Procedure

Using the procedure of Preparation 34, 14.3 g (0.045 mol) of 4-chloro-2-dimethylamino-pyrimidine-5-carboxylic acid benzylamide and 12 g (0.21 mol) of sodium hydrogen sulfide were reacted to give 5.7 g of the title compound, mp 175-178° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-1ddb2f6d95504ecbb465d4bbccdaceb1
Source dataset
uspto-grants-1999_12
Patent number
US06001863

Reaction notes

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