2,5-Dichloropyrimidine → HCID 117727732, compound

HRID 61168Notes

Reaction equation

HRID 61168 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][N:13]=1)=[O:11].Cl[C:23]1[N:28]=[CH:27][C:26]([Cl:29])=[CH:25][N:24]=1>>[Cl:29][C:26]1[CH:25]=[N:24][C:23]([NH:1][CH2:2][C@@H:3]2[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]2[C:10]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][N:13]=2)=[O:11])=[N:28][CH:27]=1

Participants

3

Reactant 2

HCID 5906412,5-DichloropyrimidineHCID 117727788((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(isoquinolin-1-yl)methanone

Product 1

HCID 117727732HCID 117727732, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A1, using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(isoquinolin-1-yl)methanone and 2,5-dichloropyrimidine. ESI-MS (m/z): 396 [M+1]+.

Sources & evidence

ORD record
ord-52b97782bc8d42f98e82f91152de508e
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

Loading…