HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxide (P4O10) → Metrafenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxide (P4O10) | HCID 14812 | — |
| Reactant | 3,4,5-Trimethoxytoluene | HCID 80922 | — |
| Reactant | 3-Bromo-6-methoxy-2-methylbenzoic acid | HCID 2752992 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Metrafenone | HCID 6451057 | — |
Reaction Steps
63B (240 g, 1.0 mol) is reacted with 3,4,5-trimethoxytoluene (182 g; 1.0 mol) in the presence of P2O5 (1.0 kg) and dichloromethane as described in Example 6 yielding white crystals, 220 g (54% ), mp 89-91° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06001883 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-49d02edb453e470182387a31e8d99b2e |
| Source note | uspto-grants-1999_12 |