HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 611719Generated: October 27, 2026
N-methyl-2-pyrrolidone → 6,6'-Dimethyl-2,2',3',4'-tetramethoxy-5-trifluoromethyl-benzophenone
https://huagongshe.com/reaction/611719
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | Sodium Trifluoroacetate | HCID 517019 | — |
| Reactant | Metrafenone | HCID 6451057 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 6,6'-Dimethyl-2,2',3',4'-tetramethoxy-5-trifluoromethyl-benzophenone | HCID 22671393 | — |
Reaction Steps
A mixture of 63C (6.15 g, 0.015 mol), sodium trifluoroacetate (9.52 g, 0.07 mol), copper-(I)iodide (13.37 g, 0.07 mol) and 1-N-methyl-2-pyrrolidinone (100 ml) is heated to 160° C. for 118 hours. The reaction mixture is cooled to room temperature and diluted with ether and water. The organic phase is separated and concentrated and the residue is purified by column chromatography (petrol ether:ethyl acetate, 95:5 v/v) yielding the pure product as white crystals, 1.3 g, (22%) having a melting point of 95-96° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06001883 |
|---|
| Source dataset | uspto-grants-1999_12 |
|---|
| ORD ID | ord-ce0e17e919c2490d9f747aa244f6f4a0 |
|---|
| Source note | uspto-grants-1999_12 |
|---|
