反应详情

A mixture of potassium methylate in methanol (15 ml, 15%) and 2-fluoro-6-trifluoromethylbenzoic acid (2.08 g, 0.01 mol) is heated to reflux with stirring for 40 hours. Upon cooling to room temperature water is added. The reaction mixture is filtered and the filtrate is acidified with concentrated hydrochloric acid. The solid material is collected by filtration, washed with water and dried yielding white crystals, 1.4 g (64%), mp 130-131° C.

1. temperatureis heated
2. temperatureto reflux
3. additionis added
4. filtrationThe reaction mixture is filtered
5. filtrationThe solid material is collected by filtration
6. washwashed with water
7. customdried
8. customyielding white crystals, 1.4 g (64%), mp 130-131° C.