Phosphorus oxide (P4O10) → 6'-Methyl-2,2',3',4'-tetramethoxy-6-trifluoromethyl-benzophenone

HRID 611721Notes

Reaction equation

HRID 611721 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[C:4]=1[C:5]([OH:7])=O.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH3:28])[CH:21]=[C:22]([O:26][CH3:27])[C:23]=1[O:24][CH3:25].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>ClCCl>[CH3:28][C:20]1[C:21]([C:5](=[O:7])[C:4]2[C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=[CH:11][C:3]=2[O:2][CH3:1])=[C:22]([O:26][CH3:27])[C:23]([O:24][CH3:25])=[C:18]([O:17][CH3:16])[CH:19]=1

Participants

5

Reactant 3

HCID 14812Phosphorus oxide (P4O10)HCID 809223,4,5-TrimethoxytolueneHCID 150175332-Methoxy-6-(trifluoromethyl)benzoic acid

Product 1

HCID 177769996'-Methyl-2,2',3',4'-tetramethoxy-6-trifluoromethyl-benzophenone

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

65A (1.38 g, 0.00625 mol) is reacted with 3,4,5-trimethoxytoluene (1.14 g; 0.00625 mol) in the presence of P2O5 (5.0 g) and dichloromethane (100 ml) as described in Example 6 yielding white crystals, 1.68 g (69.8% ), mp 69-70° C.

Sources & evidence

ORD record
ord-4300a4ec53ba413680062781d1f46eff
Source dataset
uspto-grants-1999_12
Patent number
US06001883

Reaction notes

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