Trifluoroacetic acid → HCID 70143916, compound

Participants

Reaction Steps

To a solution of the piperazinone from Step J (60 mg, 0.115 mmol) in 2 mL of dichloromethane at 0 ° C. was added trifluoroacetic acid (1.0 mL), and the reaction was allowed to warm to room temperature. After 6 hours, the solution was concentrated in vacuo, taken up in CH2Cl2, washed with dilute aq. NaHCO3 soln., dried (Na2SO4), filtered, and concentrated in vacuo to provide the crude product. After conversion to the HCl salt, the product was isolated (62 mg) as a 9:1 mixture of diastereomers. FAB ms: 422 (M+1). Anal. Calc for C22H20ClN5O2.2.10 HCl. 1.00 H2O: C, 51.16; H, 4.70; 0, 13.56. Found: C, 51.21; H, 4.70; 0, 12.66.

Provenance & Evidence