HCID 117727669, compound → HCID 117727804, compound

HRID 61189Notes

Reaction equation

HRID 61189 reaction equation
NC[C@@H]1[C@H](C)CCCN1C(C1C=C(C)C=CC=1C1C=NN(C)C=1)=O.[F:25][C:26]1[CH:52]=[CH:51][C:29]([C:30]([N:32]2[CH2:37][CH2:36][CH2:35][C@@H:34]([CH3:38])[C@H:33]2[CH2:39][N:40]2C(=O)C3C(=CC=CC=3)C2=O)=[O:31])=[C:28]([C:53]2[N:58]=[CH:57][CH:56]=[CH:55][N:54]=2)[CH:27]=1>>[NH2:40][CH2:39][C@@H:33]1[C@H:34]([CH3:38])[CH2:35][CH2:36][CH2:37][N:32]1[C:30]([C:29]1[CH:51]=[CH:52][C:26]([F:25])=[CH:27][C:28]=1[C:53]1[N:54]=[CH:55][CH:56]=[CH:57][N:58]=1)=[O:31]

Participants

3

Reactant 2

HCID 117727669HCID 117727669, compoundHCID 117728145((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

Product 1

HCID 117727804HCID 117727804, compound

Procedure

The title compound was prepared following the same general protocol as described for ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone in Example A1 using 2-(((2S,3R)-1-(4-fluoro-2-(pyrimidin-2-yl)benzoyl)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione. MS (ESI) 329 (M+H).

Sources & evidence

ORD record
ord-d8097b7e5a694ead83b15bb4ea380cec
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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