2,5-Dichloropyrimidine → HCID 117728337, compound

HRID 61197Notes

Reaction equation

HRID 61197 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=1[C:19]1[N:24]=[CH:23][CH:22]=[CH:21][N:20]=1)=[O:11].Cl[C:26]1[N:31]=[CH:30][C:29]([Cl:32])=[CH:28][N:27]=1>>[Cl:32][C:29]1[CH:28]=[N:27][C:26]([NH:1][CH2:2][C@@H:3]2[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]2[C:10]([C:12]2[C:13]([C:19]3[N:20]=[CH:21][CH:22]=[CH:23][N:24]=3)=[CH:14][CH:15]=[CH:16][C:17]=2[F:18])=[O:11])=[N:31][CH:30]=1

Participants

3

Reactant 2

HCID 5906412,5-DichloropyrimidineHCID 117727763((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(2-fluoro-6-(pyrimidin-2-yl)phenyl)methanone

Product 1

HCID 117728337HCID 117728337, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A1 using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(6-fluoro-2-(pyrimidin-2-yl)phenyl)methanone and 2,5-dichloropyrimidine. ESI-MS (m/z): 441 [M+1]+.

Sources & evidence

ORD record
ord-d12bac0ae8784878935da38b0bad79da
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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