HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 611986Generated: October 27, 2026
Chloroacetyl chloride → N-[4-[(3-Bromophenyl)amino]-3-cyano-6-quinolinyl]-2-chloroacetamide
https://huagongshe.com/reaction/611986
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Amino-4-(3-bromophenylamino)quinoline-3-carbonitrile | HCID 9967712 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[4-[(3-Bromophenyl)amino]-3-cyano-6-quinolinyl]-2-chloroacetamide | HCID 10273341 | 43.9% |
Reaction Steps
Triethylamine(0.359 g, 3.55 mmol) and chloroacetyl chloride (0.402 g, 3.55 mmol) were added to an ice cold solution of 1.00 g (2.96 mmol) of 6-amino-4-[(3-bromophenyl)amino]-3-quinolinecarbonitrile in 12 mL of tetrahydrofuran under N2. After stirring overnight at 25° C., volatile material was removed and the residue was slurried in water and collected. Recrystallization from methanol gave 0.540 g of tan solid: mass spectrum (electrospray, m/e): M+H 415, 417.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06002008 |
|---|
| Source dataset | uspto-grants-1999_12 |
|---|
| ORD ID | ord-67e7184988b1403ea870e40260bee0be |
|---|
| Source note | uspto-grants-1999_12 |
|---|
