HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 611994Generated: October 31, 2026
Ammonium Hydroxide → 3-Carbethoxy-4-chloro-6,7-dimethoxylquinoline
https://huagongshe.com/reaction/611994
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178469636 | HCID 178469636 | — |
| Product | 3-Carbethoxy-4-chloro-6,7-dimethoxylquinoline | HCID 10357178 | — |
Reaction Steps
A mixture of 28.8 g of 3-carbethoxy-4-hydroxy-6,7-dimethoxyquinoline and 16.6 ml of phosphorous oxychloride was stirred at 1 10° C. for 30 min, cooled to 0° C., and treated with a mixture of ice and ammonium hydroxide. The resulting grey solid was filtered, washed with water and ether, and dried, mp 147-150° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06002008 |
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| Source dataset | uspto-grants-1999_12 |
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| ORD ID | ord-c7dcca4472174b7fb6342f271a619a52 |
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| Source note | uspto-grants-1999_12 |
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