HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 611996Generated: October 30, 2026
Ammonia → 4-[(3-Bromophenyl)amino]-6,7-dimethoxy-3-quinolinecarboxamide
https://huagongshe.com/reaction/611996
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-carboxylic Acid | HCID 5328878 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-[(3-Bromophenyl)amino]-6,7-dimethoxy-3-quinolinecarboxamide | HCID 5328879 | — |
Reaction Steps
A mixture of 4.03 g of 4-[(3-bromophenyl)amino]-6,7-dimethoxy-3-quinolinecarboxylic acid, 3.24 g of carbonyldiimiazole, and 100 ml of dimethylformamide was heated at 55 for 30 m, cooled to 0° C., and saturated with ammonia gas. After warming to 25 the resulting solution was stirred for 45 m, heated at 50, and evaporated to remove dimethylformamide. The residue was stirred with water, and the resulting solid was filtered, washed with water, and dried. Recrystallization from acetone gave a grey solid, mp 239-242° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06002008 |
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| Source dataset | uspto-grants-1999_12 |
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| ORD ID | ord-1c5c6e904ea84bb0a9bc4984b6ae9d9e |
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| Source note | uspto-grants-1999_12 |
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