5-Amino-2-chloro-4-fluorophenol → 4-(4-Chloro-2-fluoro-5-hydroxy-phenylamino)-7-(3-chloro-propoxy)-6-methoxy-quinoline-3-carbonitrile

HRID 612035노트

반응식

HRID 612035 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:15]=[C:14]2[C:9]([C:10](Cl)=[C:11]([C:16]#[N:17])[CH:12]=[N:13]2)=[CH:8][C:7]=1[O:19][CH3:20].C(=O)([O-])OC.[Cl:26][C:27]1[C:33]([OH:34])=[CH:32][C:30]([NH2:31])=[C:29]([F:35])[CH:28]=1.Cl.N1C=CC=CC=1>C(OCCO)C>[Cl:26][C:27]1[C:33]([OH:34])=[CH:32][C:30]([NH:31][C:10]2[C:9]3[C:14](=[CH:15][C:6]([O:5][CH2:4][CH2:3][CH2:2][Cl:1])=[C:7]([O:19][CH3:20])[CH:8]=3)[N:13]=[CH:12][C:11]=2[C:16]#[N:17])=[C:29]([F:35])[CH:28]=1

참가 물질

6

반응물 4

HCID 1586545-Amino-2-chloro-4-fluorophenolHCID 4585885MethylcarbonateHCID 10176127Pyridinium chlorideHCID 112206374-Chloro-7-(3-chloropropoxy)-6-methoxyquinoline-3-carbonitrile

생성물 1

HCID 224665914-(4-Chloro-2-fluoro-5-hydroxy-phenylamino)-7-(3-chloro-propoxy)-6-methoxy-quinoline-3-carbonitrile

시약·촉매·용매 1

HCID 8076Glycol monoethyl ether용매

실험 절차

By using the above method, starting with 3 g of 7-(3-chloro-propoxy)-4-chloro-6-methoxy-quinoline-3-carbonitrile, 2.35 g of the methyl carbonate of 4chloro-2-fluoro-5-hydroxy-aniline, and 1.1 g of pyridine hydrochloride in 30 ml of 2-ethoxyethanol, 1.7 g of the title compound was obtained as a crystalline solid: mass spectrum (electrospray, m/e) M+H 435.8, 437.8.

출처 및 근거

ORD 기록
ord-ca1e817cf10148a4bcf37d015f3a4b8b
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06002008

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