HCID 117727761, compound → ((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)methanone

HRID 61204Notes

Reaction equation

HRID 61204 reaction equation
NC[C@@H]1[C@H](C)CCCN1C(C1C=C(C)C=CC=1C1C=NN(C)C=1)=O.[F:25][C:26]1[C:52]([F:53])=[CH:51][C:29]([C:30]([N:32]2[CH2:37][CH2:36][CH2:35][C@@H:34]([CH3:38])[C@H:33]2[CH2:39][N:40]2C(=O)C3C(=CC=CC=3)C2=O)=[O:31])=[C:28]([C:54]2[N:59]=[CH:58][CH:57]=[CH:56][N:55]=2)[CH:27]=1>>[NH2:40][CH2:39][C@@H:33]1[C@H:34]([CH3:38])[CH2:35][CH2:36][CH2:37][N:32]1[C:30]([C:29]1[CH:51]=[C:52]([F:53])[C:26]([F:25])=[CH:27][C:28]=1[C:54]1[N:55]=[CH:56][CH:57]=[CH:58][N:59]=1)=[O:31]

Participants

3

Reactant 2

HCID 117727761HCID 117727761, compoundHCID 117728145((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

Product 1

HCID 117727894((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)methanone

Procedure

The title compound was prepared following the same general protocol as described for ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone in Example A1 using 2-(((2S,3R)-1-(4,5-difluoro-2-(pyrimidin-2-yl)benzoyl)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione. MS (ESI) 347 (M+H).

Sources & evidence

ORD record
ord-7b3ef390fcb9474bafa9a8c5483d5156
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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