2-Fluoro-5-(trifluoromethyl)pyridine → HCID 117727639, compound

HRID 61205Notes

Reaction equation

HRID 61205 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[CH:17]=[C:16]([F:18])[C:15]([F:19])=[CH:14][C:13]=1[C:20]1[N:25]=[CH:24][CH:23]=[CH:22][N:21]=1)=[O:11].F[C:27]1[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][N:28]=1>>[F:19][C:15]1[C:16]([F:18])=[CH:17][C:12]([C:10]([N:4]2[CH2:5][CH2:6][CH2:7][C@@H:8]([CH3:9])[C@H:3]2[CH2:2][NH:1][C:27]2[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][N:28]=2)=[O:11])=[C:13]([C:20]2[N:21]=[CH:22][CH:23]=[CH:24][N:25]=2)[CH:14]=1

Participants

3

Reactant 2

HCID 54637542-Fluoro-5-(trifluoromethyl)pyridineHCID 117727894((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)methanone

Product 1

HCID 117727639HCID 117727639, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A1 using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)methanone and 2-fluoro-5-(trifluoromethyl)pyridine. ESI-MS (m/z): 492 [M+1]+. 1H NMR (300 MHz, DMSO-d6) δ 9.00-6.55 (m, 9H), 4.85-2.75 (m, 5H), 2.00-0.65 (m, 8H).

Sources & evidence

ORD record
ord-13116e13a88f431a89dc77691b3533a0
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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