HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-4-nitroaniline → 2-Cyano-3-(2-methyl-4-nitrophenyl)acrylic Acid Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-4-nitroaniline | HCID 7441 | — |
| Reactant | 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester | HCID 78943 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Cyano-3-(2-methyl-4-nitrophenyl)acrylic Acid Ethyl Ester | HCID 54355097 | — |
Reaction Steps
A mixture of 2-methyl-4-nitroaniline (38.0 g, 250 mmol), ethyl (ethoxymethylene)-cyanoacetate (50.8 g, 300 mmol), and 200 ml of toluene was refluxed for 24 h, cooled, diluted with 1:1 ether-hexane, and filtered. The resulting white solid was washed with hexane-ether and dried to give 63.9 g, mp 180-210° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06002008 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-0f65c7ca188d43fea82c1e23360867dd |
| Source note | uspto-grants-1999_12 |