反应详情

To a stirred mixture of 6-amino-4-[(3-bromophenyl)amino]-8-dimethylaminomethyl-3-quinolinecarbonitrile (0.20 g, 0.50 mmol) and 1.5 ml of acetic acid at 25° C. was added 0.14 ml (1.5 mmol) of acetic anhydride. After 60 m volatile matter was evaporated off under vacuum. The residue was stirred with sodium bicarbonate solution. The resulting solid was filtered off, washed with water, dried, and recrystallized from isopropanol-hexane to give a light yellow solid, mp 162-167° C.

1. customAfter 60 m volatile matter was evaporated off under vacuum
2. filtrationThe resulting solid was filtered off
3. washwashed with water
4. customdried
5. customrecrystallized from isopropanol-hexane
6. customto give a light yellow solid, mp 162-167° C.